Successful management of adult hemophagocytic lymphohistiocytosis with an etoposide-containing regimen: Case report and literature review

نویسندگان

چکیده

Objective: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder characterized by hyperimmune response. Although HLH well described in the pediatric population, less known about appropriate management adults. Despite inclusion of etoposide society protocols, some clinicians refrain from using it due to its cytotoxicity and potential adverse effects. Case: We report here case 43-year-old male presenting with fever pancytopenia, who was diagnosed following further evaluation. The patient immediately started HLH-2004 initial protocol, which consisted dexamethasone, etoposide, cyclosporine, IVIG. Symptoms improved after 2 weeks treatment. Subsequent bone marrow biopsy showed normal results, achieved complete remission, leading termination treatment 12th week protocol. At 8 months post-treatment, remained recurrence-free hematological biochemical test results. Conclusion: This underscores importance considering etoposide-containing regimens, particularly for medically fit patients.

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ژورنال

عنوان ژورنال: Medical Science and Discovery

سال: 2023

ISSN: ['2148-6832']

DOI: https://doi.org/10.36472/msd.v10i7.975